Effect of polyphloretin phosphate (a prostaglandin receptor-blocking drug) on fertility of male rats

Abstract

No significant suppression in fertility and libido was evident by implanting Silastic rods containing 25perc. and 50 perc. polyphloretin phosphate, a prostonoid receptor-blocking drug, adjacent to the epididymis of rats. The treatment neither produced any significant deterioration of health nor development of undesirable side effects. Possible reasons for the failure of polyphloretin phosphate to effect fertility are discussed.