Journal Articles
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Item Retrospective analysis of renal histology in asymptomatic patients with probable chronic kidney disease of unknown aetiology in Sri Lanka(2013) Wijetunge, S.; Ratnatunga, N .V. I.; Abeysekera, D. T .D .J.; Wazil, A. W .M; Selvarajah, M.; Ratnatunga, C. N.Item Kidney disease is preventable with early detection(2013-06-30) Aloysius, C.Item Tubulointerstitial damage as the major pathological lesion in endemic chronic kidney disease among farmers in North Central Province of Sri Lanka.(2013-01-21) Nanayakkara, S et alChronic kidney disease of uncertain etiology (CKDu) in North Central Province of Sri Lanka has become a key public health concern in the agricultural sector due to the dramatic rise in its prevalence and mortality among young farmers. Although cadmium has been suspected as a causative pathogen, there have been controversies. To date, the pathological characteristics of the disease have not been reported. Histopathological observations of 64 renal biopsies obtained at Anuradhapura General Hospital from October 2008 to July 2009 were scored according to Banff 97 Working Classification of Renal Allograft pathology. The correlations between the histological observations and clinical parameters were statistically analyzed. Interstitial fibrosis and tubular atrophy with or without nonspecific interstitial mononuclear cell infiltration was the dominant histopathological observation. Glomerular sclerosis, glomerular collapse, and features of vascular pathology such as fibrous intimal thickening and arteriolar hyalinosis were also common. Although hypertension was identified as one of the common clinical features among the cases, it did not influence the histopathological lesions in all the cases. This study concludes that tubulointerstitial damage is the major pathological lesion in CKDu. Exposure(s) to an environmental pathogen(s) should be systematically investigated to elucidate such tubulointerstitial damage in CKDu.Item Epidemiology of Chronic Kidney Disease in a Sri Lankan population : experience in a tertiary care centre(2011) Wijewickrama, E.S; Weerasinghe, D; Sumathipala, P.S; Horadagod, C; Lanarolle, R.D; Sheriff, R. MHItem Drinking water quality assessment towards "chronic kidney disease of unknown etiology (CKDu)" in north central province (NCP) of Sri Lanka(2012) Wasana, H.M.S; Aluthpatabendi, D; Bandara, JItem Water quality and chronic kidney disease of unknown aetiology (CKDU) in the north central province of Sri Lanka(2012) Nawaratene, A.N; Galkaduwa, M.B; Devesurendra, A.M; Samaranayake, S.A; Ramanan, EItem Arsenic and hardness in ground water from chronic disease of unknown etiology (CKDU) prevalent areas and non-ckdu prevalent areas in Sri Lanka(2012) Fonseka, S.; Jayasumana, C.; Jayalath, K.; Amarasinghe, M; Senanayake, K; Wijewardhene, C.; Samarasinghe, D; Dahanayake, K; Mahamithawa, P; Paranagama, PItem Health impacts from heavy metals in ground water and rice in Anuradhapura, Sri Lanka(2012) Kodituwakku, S.P.M.; Weragoda, S.K.; Kawakami, T.; Serikawa, Y.Item Geochemical evidences from soil and water leading to chronic renel failure of unknown etiology in the dry zone Sri Lanka(2012) Jayawardana, D.T.; Pitawala, H.M.T.G.A.; Ishiga, H.Item Arsenic and other heavy metals in rice from Sri Lanka preliminar6y results with ICP-MS(2012) Chandrajith, R.; Dissanayake, N.; Dissanayake, C.B.