Journal Articles

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    Health impacts from heavy metals in ground water and rice in Anuradhapura, Sri Lanka
    (2012) Kodituwakku, S.P.M.; Weragoda, S.K.; Kawakami, T.; Serikawa, Y.
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    Challenges ahead: water quality and human health
    (Post Graduate Institute of Science, Peradeniya, Sri Lanka in collaboration with Toyama Prefretural University, Japan, 2012-03) Ileperuma, O.; Priyantha, N.; Navaratne, A.; Yatigammana, S.; Weragoda, S.
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    Chronic Kidney Disease of unknown etiology (CKDu) and Arsenic poisoning due to Illegal pesticides
    (2011) de Silva, N.; Paranagama, P.; Amarasinghe, M.; Senanayake, K.; Dahanayake, K.; Jayasumana, C.; Mahamithawa, P.; Rajakaruna, L.; Samarasinghe, D.; Fonseka, S.
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    Histopathological changes in liver and renal tissues in Wistar rats given bore well water from CKDu endemic areas in North Central Province
    (Sri Lanka Medical Association, 2012-06) Thammitiyagodage, M.G.; Rathnayake, C.; Gunatillaka, M.M.; Ekanayake, N; Jayatissa, R; Gunarathne, U.K.S.C.; Jayathilake, W.M.M.U.
    Introduction: Chronic kidney disease (CKD) is prevalent in North Central Province of Sri Lanka. Aims: Observe the histopathological changes in Liver and Kidney tissues after giving well water from CKD endemic areas. Methods: Three villages were selected after completing a questionnaire. Results of the questionnaire and number of CKD patients in the locality were taken as the selection criteria of wells. Well number one and two were selected from New Town Medirigiriya and Bisobandaragama from Medirigiriya division and third well was selected from Divuldamana from Dimbulagala. Ten rats were assigned to each group with equal male female ratio. Test rats were given well water from selected wells 1, 2 and 3 whilst control group was given tap water from Colombo. Experiment was conducted for fifteen months Results: Hepatocellular carcinorma developed in four rats given well water from Medirigiriya and one rat each from Bisobanadaragama and Divuldamana. Five rats from Bisobandaragama developed hepatitis. None of the animals given tap water from Colombo had malignant changes or hepatitis. Severe tubular and glomerular lesions were observed in test groups compared to control. There was a statistically significant difference between Tubular lesion index in all three test groups compared to control group (p<0.05). Significantly high Glomerular lesion index was observed in animals given well water from Divuldamana (p<0.05). Some environmental toxin in water can trigger hepatocellular carcinoma in rats. There is a strong association between consumption of bore well water from CKD endemic areas and development of CKD in rats.
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    Aetiological factors of Chronic Kidney Disease in the North Central Province
    (COLLEGE OF COMMUNITY PHYSICIANS OF SRI LANKA, 2012-06) Wanigasuriya, K
    Abstract Introduction Chronic kidney disease of unknown aetiology is a major health care problem in the North Central Province of Sri Lanka. During the last decade several researches were undertaken to identify the prevalence and aetiology of the disease. Fifteen manuscripts published in peer-reviewed scientific journals and two peer reviewed abstracts of were included in the review. Results The disease mainly affects males from poor socio-economic backgrounds who are involved in paddy farming . Mild proteinuria was present but urinary sediments were normal. Renal biopsies were reported as interstitial nephritis. Significant predictors of kidney disease in these patients included age, history of smoking, being under treatment for hypertension and drinking well water in the fields. Studies on heavy metal and ochratoxin exposure have revealed conflicting results. Fluoride content of well water in all these areas exceeded the WHO recommended level of 0.6 mg/L. Water in all areas was alkaline which could facilitate mobilization of fluoride from minerals indicating a fluoride mediated mechanism for renal damage. Conclusion The aetiology of CKDu in NCP of Sri Lanka is probably multi-factorial involving one or more environmental factors and a possible genetic predisposition in vulnerable populations.
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    Chronic renal failure among farm families in cascade irrigation systems in Sri Lanka associated with elevated dietary cadmium levels in rice and freshwater fish (Tilapia)
    (2008) Bandara, J. M. R. S.; Senevirathna, D. M. A. N.; Dasanayake, D. M. R. S. B.; Herath, V.; Bandara, J. M. R. P.; Abeysekara, T.; Rajapaksha, K. H.