4.Journals Published in Sri Lanka

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Author: search.filters.author.Ratnasooriya, W.D.Subject: search.filters.subject.Animal reproduction

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    Effect of polyphloretin phosphate (a prostaglandin receptor-blocking drug) on fertility of male rats
    (1983) Ratnasooriya, W.D.; Lionel, N.D.W.
    No significant suppression in fertility and libido was evident by implanting Silastic rods containing 25perc. and 50 perc. polyphloretin phosphate, a prostonoid receptor-blocking drug, adjacent to the epididymis of rats. The treatment neither produced any significant deterioration of health nor development of undesirable side effects. Possible reasons for the failure of polyphloretin phosphate to effect fertility are discussed.
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    Effect of oxytocin on fertility of male rats
    (University of Colombo. Colombo, 2004) Ratnasooriya, W.D.; Jayakody, J.R.A.C.; Dharmasiri, M.G.
    It is now recognised that oxytocin (OT) modulates several aspects of male reproduction. However, its overall impact on male fertility remains unknown. Thus, the aim of this study was to examine the effect of OT om male fertility. This was investigated in rats using three doses [0.1 international units (IU) of OT once a day (n=9) twice a day and thrice a day , given intrapertioneally for 7 consecutive days] and a non competitive serial mating trial (on days 1,3 and 7 of treatment and day 7 post treatment). The OT caused marked oligozoospermia without provoking toxic side effects (in terms of teratozoospermia, overt signs of toxicity, renotoxicity , hepatotoxicity or haemotoxicity) or compromising libido, mating peroformance and fertility (in terms of quantal pregnance, number of uterine implants and indices of implantation and fertility), The oligozoospermia was mediated by retrograde ejaculation and by impairment of ejaculatory contraction of vas (as judged by inhibition of elctrically elicited contraction of isolated vas) and probably epididymis. It is possible that OT analogues may be developed as post-testicular male contraceptives.